Interese: recunoastere moleculara, nanotehnologie

Detalii:
Sunt implicat in mai multe programe de cercetare avand ca obiective sinteza si caracterizarea (chimica si preclinica) a unei serii de conjugate polimer-medicament cu activitate antitumorala

Publicaţii relevante:
• V. Sunel, M. Popa, A. D. Stoican, A. A. Popa, C. V. Uglea. Poly(maleic anhydride-alt-vinyl acetate) conjugate with alkylating afents. I. Synthesis and physico-chemical characterization. Materiale Plastice, 45, pp. 149-153, 2008.
• M. Popa, V. Sunel, N. Dulea, A. A. Popa, R. M. Ottenbrite and C. V. Uglea. Antitumoral Activity Induced by Alkylating Agents Conjugated toPoly(Maleic Anhydride-alt-Vinyl Acetate. Journal of Bioactive & Compatible Polymers, 22(6), pp. 651-666, 2007.
• Ioan I. Nedulescu and Constantin V. Uglea. Biological Activity of Oxidized Polysaccharides. Modified Fibres for Medical and Specialty Applications, pp. 124-637, 2005.
• C. V. Uglea, A. Parv, M. Corjan, A. D. Dumitriu, R. M. Ottenbrite. Biodistribution and antitumor activity induced by carboxymethylcellulose conjugates. Journal Bioactive and Compatible Polymers, , 20, pp. 571-583, 2005.
• T. Buruiana, D. Spridon, E. Buruiana, V. Hefco, C. V. Uglea. Polyurethane based on dihydroxamic acids. J. Biomat. Sci., Polymer Ed., , 12, pp. 1159-1170, 2000.
• D. Spridon, C. V. Uglea. Biological activity of hydroxamic compounds. In Biomaterial and Bioengineering Handbook. Marcel Dekker, Inc., , 2000.
• Iuliana Popa, C. Beldie, Offenberg Harry, Constantin V. Uglea. Benzocaine modified maleic anhydride copolymers. I. poly(maleic anhydride-co-vinyl acetate), poly(maleic anhydride-co-methyl methacrylate) and poly(maleic anhydrideco-styrene). Europeean Polymer Journal, 33(9), pp. 1511-1514, 1997.
• Constantin V. Uglea , Mariana Croitoru. Transport of amino acids through organic liquid membranes. III. The alkaline ion role. Journal of Membrane Science, 133(1), pp. 127-131, 1997.
• D. Spridon, L. Panaitescu, D. Ursu, C. V. Uglea, I. Popa, R. M. Ottenbrite. Synthesis and biocompatibility of maleic anhydride(ma) copolymers. I. ma-vinyl acetate, ma-methylmethacrylate and ma-styrene. Polymer International, 43(2), pp. 175-181, 1997.
• Constantin V. Uglea, L. Panaitescu, D. Spridon, D. Ursu, I. Popa, R. M. Ottenbrite. Biological activity of maleic anhydride copolymers. J. Biomat. Eci., Polymer Ed., , 8, pp. 269-277, 1996.
• C. V. Uglea. Liqui Cromatography of Oligomers. Marcel Dekker Inc., New York, 1996.
• Constantin V. Uglea, I. Albu, A. Vatajanu, M. Croitoru, S. Antoniu, L. Panaitescu, R. M. Ottenbrite. Drug Delivery Systems Based on Inorganic Materials:I Synthesis and Characterization of a Zeolite-Cyclophosphamide system. Journal Biomaterial mScience, Polymer Edition, 6(7), pp. 633-677, 1995.
• C. V. Uglea, Cristina Dumitriu-Medivighi. Medical applications of synthetic oligomers. In S. Dumitriu (ed.), Polymeric Biomaterials. Marcel Dekker, Inc., , 1994.
• C. V. Uglea, I. Albu, A. Vatajanu, M. Croitoru, D. Iurea, M. Isac, R. M. Ottenbrite. Polyanionic Polymers. I. Synthesis, Characterisation, and Potential Medical Applications of Benzocaine Modified Carboxymethylcellulose. Journal Bioactive& Compatible Polymers, 9, pp. 443-451, 1994.
• C. V. Uglea, I. Albu, A. Vatajanu, M. Croitoru, D. Iurea, M. Isac, R. M. Ottenbrite. Polyanionic Polymers. ISynthesis, Characterisation, and Potential Medical Applications of Benzocaine Modified Carboxymethylcellulose. Journal Bioactive& Compatible Polymers, 9, pp. 443-451, 1994.
• Constantin V. Uglea, A. Vatajanu, Offenberg Harry, Alexandru Grecianu, R. M. Ottenbrite, Ioan I. Negulescu. Benzocaine modified maleic anhydride-cyclohexyl-1, 3-dioxepin copolymer:preparation and potential medical applications. Polymer, 34, pp. 3298-3301, 1993.
• Constantin V. Uglea , Cristinel V. Zanoaga. Transport of amino acids through organic liquid membranes. IIAspects of the mechanism. Journal of Membrane Science, 65(1-2), pp. 47-50, 1992.
• C. V. Uglea, I. I. Hegulescu. Synthesis and characterization of oligomers. CRC Press, Boca Raton, USA, 1992.
• Constantin V. Uglea, Cristinel V. Zanoaga. Transport of amino acids through organic liquid membranes. I p-aminobenzoic acid. Journal of Membrane Science, 47(3), pp. 285-292, 1989.
• C. V. Uglea, H. Offenberg, C. Cascaval. Synthesis and characterization of self-colored poly(ethylene terephthalate). Eur. Polymer Journal, 21, pp. 681-684, 1985.
• C. V. Uglea, A. Mihaesu. Unperturbed dimensions and intrinsic viscosity-molecular weight relationship of copolyesters poly(ethylene terephthalate-co-ethylene isophthalate). Journal of Chemical Technology& Biotechnology Chemical Technology, 35(1), pp. 1-4, 1985.
• Constantin Uglea, Ioan Corduneanu, Ioan Negulescu. Characterization of polyesters:thermo-oxidative degradation. Monatschefte fur Chemie, 115(3), pp. 349-356, 1984.
• M. Bezdadea, C. V. Uglea. Matrix polymerisation of poly(vinyl acetate). British Polymer Journal, 15(3), pp. 129-132, 1983.
• C. V. Uglea, V. Stan. The characterization of dope deyed poly(ethulene yerephthalate). British Polymer Journal, 14(2), pp. 39-44, 1982.
• C. Cincu, C. V. Uglea. Dilute solution properties of alternating copolymers from methacrylonitrile and styrene and methacrylonitrile and alphamethylstyrene. Die Makromoleculare Chemie, 177(8), pp. 2457-2468, 1976.
• C. V. Uglea. Hemicellulose characterization. Die Makromoleculare Chemie, 175, pp. 1535-1542, 1974.
• D. Feldman, C. V. Uglea, V. Nuta, M. Popa. Characterization du poly(chlorure de vinyl). Analusis, 1(1), pp. 305-309, 1972.
• D. Feldman, C. V. Uglea, N. Simionescu . Contribution au fractionnement des copolym’eres. II Copolymeres ternaires acrylonitrule-acetate de vinyle-alphamethylstyrene. Journal of Polymer Science, Part A-1:Polymer Chemistry, 7(2), pp. 439-448, 1969.